Epic Quest Bio The case files
Case No. 108 · the exotic forty · have you seen this molecule?

Nickel-pincer cofactor

the first pincer complex ever found in an enzyme

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Nickel-pincer cofactor, front view, against a height chart in nanometers
FRONT
Nickel-pincer cofactor, side view
SIDE · PDB 5HUQ

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, ruled every 0.1 nm. Mugshot: the crystal structure, cut free at the enzyme’s lysine. The bacterium that makes it is a few thousand times longer.

Rap sheet

Answers to
NPN, short for nickel-pincer nucleotide.
Height
1.0 nm, on its phosphate.
Weight
0.78 zeptograms.
Build
An SCS pincer around one nickel(II).
Habits
Mirrors lactic acid. Hydride suspected.
Associates
LarC, the first cyclometallase found in nature, snaps the nickel in.
Prior art
Chemists first made pincers in the 1970s. Bacteria never said a word.
Weakness
Falls apart out of its enzyme, even at −80 °C.
Last seen
Inside a bacterium that sours sauerkraut and pickles.
2

proteins are used up, a sulfur atom apiece, to build each one.
You’ve never seen one.

CASE FILE: Desguin, B. et al. (2015) A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase. Science 349, 66–69.

The poster on the street

The wanted poster for Nickel-pincer cofactor

This is the photocopied wanted poster for Nickel-pincer cofactor, No. 108 of the exotic forty. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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