Epic Quest Bio The case files
Case No. 107 · the exotic forty · have you seen this molecule?

Hypusine

the amino acid found in exactly one protein

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Hypusine, front view, against a height chart in nanometers
FRONT
Hypusine, side view
SIDE · CID 10922432

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, ruled every 0.1 nm. A yeast cell is several thousand times wider.

Rap sheet

Answers to
Hypusine, for hydroxyputrescine + lysine: a guess at its parents.
Height
1.4 nm, standing on end.
Weight
0.39 zeptograms
Build
A lysine plus the tail end of a spermidine. Long, bendy, basic.
Rarity
One protein, eIF5A. One lysine: No. 50 in you, No. 51 in yeast.
Habits
Steadies the ribosome’s P-site tRNA so stubborn prolines can join.
Relatives
Bacteria skip it: their EF-P uses a beta-lysine, or a sugar.
First seen
Loose in cow brain, a decade before its protein turned up.
Last seen
On lysine 50 of eIF5A, in nearly every cell you have.
50,000

of them in one yeast cell, give or take, all on the same lysine of the same protein.
You’ve never seen one.

CASE FILE: Shiba, T. et al. (1971) Hypusine, a new amino acid occurring in bovine brain. Biochim. Biophys. Acta 244, 523–531.

The poster on the street

The wanted poster for Hypusine

This is the photocopied wanted poster for Hypusine, No. 107 of the exotic forty. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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