Epic Quest Bio The case files
Case No. 135 · the exotic forty · have you seen this molecule?

Ice-nucleation protein InaZ

the protein that makes snow

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Ice-nucleation protein InaZ, front view, against a height chart in nanometers
FRONT
Ice-nucleation protein InaZ, side view
SIDE · AF-P06620

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, ruled every 1 nm. As tall as 40 unit cells of ice, stacked. Mugshot: an AlphaFold model, minus its loose N-terminal end.

Rap sheet

Answers to
InaZ, of the leaf bacterium Pseudomonas syringae.
Height
30 nm, standing on end: a rod of 61 coils.
Weight
197 zeptograms, all 1,200 amino acids.
Build
Threonine rows down one face that seem to line water up like ice.
Habits
Frosts leaves at −2 °C so its bacterium can feed.
Known for
The best ice-maker known. Tiny drops of water alone can stay liquid to −38 °C.
Suspected
Of seeding snow and hail. Most of fresh snow’s warmest ice-makers are biological.
First seen
In 1974: bacteria from rotting alder leaves froze water at −1.8 °C.
Last seen
On a leaf, on the outside of a bacterium, waiting for frost.
160

of them, by weight, in one ice-making site that works at −2 °C, by one estimate.
You’ve never seen one.

CASE FILE: Green, R. L. & Warren, G. J. (1985) Physical and functional repetition in a bacterial ice nucleation gene. Nature 317, 645–648.

The poster on the street

The wanted poster for Ice-nucleation protein InaZ

This is the photocopied wanted poster for Ice-nucleation protein InaZ, No. 135 of the exotic forty. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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