Epic Quest Bio The case files
Case No. 125 · the exotic forty · have you seen this molecule?

Beta-flower protein

the fold nobody had seen until AlphaFold drew it

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Beta-flower protein, front view, against a height chart in nanometers
FRONT
Beta-flower protein, side view
SIDE · AFDB A0A494VZL1

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, a line every 0.5 nm. Mugshot: an AlphaFold model, face on and side on; phenylalanines dark. A lawn daisy is about five million times wider.

Rap sheet

Answers to
A0A494VZL1. Officially “uncharacterized.”
Height
4.7 nm, petals and all.
Weight
18 zeptograms.
Build
96 amino acids, ten short strands, one shallow barrel.
Marks
Dark phenylalanines tip all five petals.
Associates
No kin by sequence; 43 distant cousins by shape.
First seen
On a screen. “It looks like a flower,” its finders wrote.
Status
A prediction, pLDDT 96. No experimental structure on file.
Last seen
In the genome of a bacterium from a freshwater lake in Korea.
210,000,000

predicted proteins, give or take, in the database it was found in.
You’ve never seen one. Neither has the Protein Data Bank.

CASE FILE: Durairaj, J. et al. (2023) Uncovering new families and folds in the natural protein universe. Nature 622, 646–653.

The poster on the street

The wanted poster for Beta-flower protein

This is the photocopied wanted poster for Beta-flower protein, No. 125 of the exotic forty. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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