Epic Quest Bio The case files
Case No. 98 · have you seen this molecule?

Alpha-hemolysin

the first protein nanopore to read DNA

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Alpha-hemolysin, front view, against a height chart in nanometers
FRONT
Alpha-hemolysin, side view
SIDE · PDB 7AHL

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, a line every 2 nm. A nose is about five million times longer.

Rap sheet

Answers to
Alpha-hemolysin, or αHL to nanopore people.
Height
10.5 nm, cap up, stem down.
Weight
390 zeptograms
Build
Seven identical parts that find each other and make a mushroom.
Habits
Lands on a membrane and punches a hole straight through.
Known for
A 1.4 nm tunnel. DNA goes through single file, dipping the current.
Origins
A bacterium that lives on skin and in noses, often unnoticed.
Last seen
A 5 mL tube marked NOSE in the freezer at HQ.
2,600,000,000,000,000

of them in a milligram of the dried protein, seven parts to a pore.
Far fewer on a nose swab. You’ve never seen one.

The poster on the street

The wanted poster for Alpha-hemolysin

This is the photocopied wanted poster for Alpha-hemolysin, No. 98. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

Not a player yet? Join the Epic Quest: the real role-playing game of Molecular Reality, a nanopore lab, with the CEO as gamemaster.