Epic Quest Bio The case files
Case No. 140 · the exotic forty · have you seen this molecule?

Hachimoji DNA

DNA with eight letters

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Hachimoji DNA, front view, against a height chart in nanometers
FRONT
Hachimoji DNA, side view
SIDE · PDB 6MIK

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, ruled every 0.2 nm. About 13,000, stacked, would span a human hair. Its twelve synthetic letters are shaded dark.

Rap sheet

Answers to
Hachimoji: Japanese for “eight letters.” G, A, C, T, P, B, Z, S.
Height
6.1 nm, this piece: 16 rungs.
Weight
16 zeptograms, this piece.
Marks
The dark band: six synthetic pairs in a row. The helix doesn’t mind.
Build
Plain B-form, 10.2–10.4 pairs a turn. Passes for ordinary DNA.
Capacity
Three bits a letter. Yours manage two.
Habits
Copied into eight-letter RNA that folds up and makes a dye glow green.
Suspected
Of showing how life elsewhere might spell. Its makers’ words: “life throughout the cosmos.”
Last seen
Being read by plain E. coli RNA polymerase, under cryo-EM, in a lab in San Diego.
280,000,000,000,000

different 16-letter strands it can spell. Plain DNA: 4.3 billion.
You’ve never seen one.

CASE FILE: Hoshika, S. et al. (2019) Hachimoji DNA and RNA: A genetic system with eight building blocks. Science 363, 884–887.

The poster on the street

The wanted poster for Hachimoji DNA

This is the photocopied wanted poster for Hachimoji DNA, No. 140 of the exotic forty. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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