Epic Quest Bio The case files
Case No. 38 · have you seen this molecule?

Cas9

the CRISPR scissors of yogurt bacteria

File sealed

The detectives are still writing this one up. The poster and the facts are below; the film and the interrogation room open soon.

Booking photographs

Cas9, front view, against a height chart in nanometers
FRONT
Cas9, side view
SIDE · PDB 6M0X

The suspect, from its real atomic coordinates. Drag to turn it. Height chart in nanometers, a line every nanometer. Its guide RNA and the DNA it’s cutting are drawn dark. A fingernail grows that far in about nine seconds.

Rap sheet

Answers to
Cas9. Went by Cas5 in its early days.
Height
12 nm, standing up. Nearly as wide.
Weight
215 zeptograms, not counting its RNA.
Build
Two lobes, with its guide RNA and target DNA between them.
Habits
Carries a mugshot: an RNA snippet of a past virus. Cuts any DNA that matches.
Origins
Streptococcus thermophilus, one of the two bacteria US law requires in yogurt.
First seen
At work in yogurt bacteria that survived viruses and kept snippets on file.
Last seen
A 5 mL tube marked YOGURT in the fridge at HQ.
17,000,000,000

live bacteria in a 6 oz cup of live-culture yogurt, give or take.
Nobody has counted the scissors. You’ve never seen one.

The poster on the street

The wanted poster for Cas9

This is the photocopied wanted poster for Cas9, No. 38. They were made for noticeboards around Boston, Cambridge and the rest of the east coast.

Found one? Scan its QR code with your phone. If you're a signed-in player, the sighting goes on your record with +1 XP.

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